Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study.
Identifieur interne : 001E36 ( Main/Exploration ); précédent : 001E35; suivant : 001E37Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study.
Auteurs : Alberto J. Espay [Canada] ; Dorcas E. Beaton ; Francesca Morgante ; Carolyn A. Gunraj ; Anthony E. Lang ; Robert ChenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Biomechanical Phenomena, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Hypokinesia (etiology), Male, Middle Aged, Parkinson Disease (complications), Pilot Projects, Psychomotor Performance (physiology), Reproducibility of Results, Severity of Illness Index, Task Performance and Analysis.
- MESH :
- complications : Parkinson Disease.
- etiology : Hypokinesia.
- physiology : Psychomotor Performance.
- Aged, Aged, 80 and over, Biomechanical Phenomena, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Pilot Projects, Reproducibility of Results, Severity of Illness Index, Task Performance and Analysis.
Abstract
Bradykinesia, characterized by slowness and decreased amplitude of movement, is often considered the most important deficit in Parkinson's disease (PD). The current clinical rating of bradykinesia in PD, based on the motor subscale of the Unified Parkinson's disease Rating Scale (UPDRS-III), does not individually weigh the impairments in speed and amplitude of rapid alternating movements. We sought to categorize movement in PD to determine whether speed and amplitude have different relationships to current measures of motor impairment and disability. Categories of speed and amplitude (normal, slow/low, and very-slow/very-low) were ascertained using an electromagnetic tracking device. Amplitude was disproportionally more affected than speed in the "off" state. UPDRS-III and the Schwab & England disability scale were worst in patients with very impaired amplitude and best in patients with normal amplitude. A similarly graded relationship was not found for categories of speed impairment. The examiner clinical global impression of change mirrored "off" state amplitude but not speed categories. Levodopa, however, normalized speed to a greater extent than amplitude. Our observations suggest that amplitude and speed impairments may be associated with different functional aspects in PD and deserve separate clinical assessment.
DOI: 10.1002/mds.22480
PubMed: 19230031
Affiliations:
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Beaton</name></author><author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name></author><author><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19230031</idno><idno type="pmid">19230031</idno><idno type="doi">10.1002/mds.22480</idno><idno type="wicri:Area/PubMed/Corpus">000E73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E73</idno><idno type="wicri:Area/PubMed/Curation">000E73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E73</idno><idno type="wicri:Area/PubMed/Checkpoint">000E73</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E73</idno><idno type="wicri:Area/Ncbi/Merge">000A35</idno><idno type="wicri:Area/Ncbi/Curation">000A35</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A35</idno><idno type="wicri:Area/Main/Merge">001F86</idno><idno type="wicri:Area/Main/Curation">001E36</idno><idno type="wicri:Area/Main/Exploration">001E36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study.</title><author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name><affiliation wicri:level="4"><nlm:affiliation>Toronto Western Research Institute, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Beaton, Dorcas E" sort="Beaton, Dorcas E" uniqKey="Beaton D" first="Dorcas E" last="Beaton">Dorcas E. Beaton</name></author><author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name></author><author><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Biomechanical Phenomena</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Hypokinesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Pilot Projects</term><term>Psychomotor Performance (physiology)</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Task Performance and Analysis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Biomechanical Phenomena</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Task Performance and Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bradykinesia, characterized by slowness and decreased amplitude of movement, is often considered the most important deficit in Parkinson's disease (PD). The current clinical rating of bradykinesia in PD, based on the motor subscale of the Unified Parkinson's disease Rating Scale (UPDRS-III), does not individually weigh the impairments in speed and amplitude of rapid alternating movements. We sought to categorize movement in PD to determine whether speed and amplitude have different relationships to current measures of motor impairment and disability. Categories of speed and amplitude (normal, slow/low, and very-slow/very-low) were ascertained using an electromagnetic tracking device. Amplitude was disproportionally more affected than speed in the "off" state. UPDRS-III and the Schwab & England disability scale were worst in patients with very impaired amplitude and best in patients with normal amplitude. A similarly graded relationship was not found for categories of speed impairment. The examiner clinical global impression of change mirrored "off" state amplitude but not speed categories. Levodopa, however, normalized speed to a greater extent than amplitude. Our observations suggest that amplitude and speed impairments may be associated with different functional aspects in PD and deserve separate clinical assessment.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Beaton, Dorcas E" sort="Beaton, Dorcas E" uniqKey="Beaton D" first="Dorcas E" last="Beaton">Dorcas E. Beaton</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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